Recent Publications

Carruthers, N. J.; Stemmer, P. M.; Media, J.; Swartz, K.; Wang, X.; Aube, N.; Hamann, M. T.; Valeriote, F.; Shaw, J.: The anti-MRSA compound 3-O-alpha-L-(2'',3''-di-p-coumaroyl)rhamnoside (KCR) inhibits protein synthesis in Staphylococcus aureus. J Proteomics 2020, 210, 103539.

Chen, X.; Ding, Y.; Forrest, B.; Oh, J.; Boussert, S. M.; Hamann, M. T.: Lemon yellow #15 a new highly stable, water soluble food colorant from the peel of Citrus limon. Food Chem 2019, 270, 251-256.

Liu, J.; Pandey, P.; Wang, X.; Adams, K.; Qi, X.; Chen, J.; Sun, H.; Hou, Q.; Ferreira, D.; Doerksen, R. J.; Hamann, M. T.; Li, S.: Hepatoprotective Tetrahydrobenzo-cyclooctabenzofuranone Lignans from Kadsura longipedunculata. J Nat Prod 2019, 82 (10), 2842-2851. PM CID:

Wang, X.; Hamann, M. T.: Marine natural products in the discovery and development of potential pancreatic cancer therapeutics. Adv Cancer Res 2019, 144, 299-314. PM CID:

Zou, Y.; Wang, X.; Sims, J.; Wang, B.; Pandey, P.; Welsh, C. L.; Stone, R. P.; Avery, M. A.; Doerksen, R. J.; Ferreira, D.; Anklin, C.; Valeriote, F. A.; Kelly, M.; Hamann, M. T.: Computationally Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean. J Am Chem Soc 2019, 141 (10), 4338-4344.

Holshouser, S.; Dunworth, M.; Murray-Stewart, T.; Peterson, Y.K.; Burger, P.A.; Chen, H.-H.; Casero, Jr., R.A.; Woster, P.M.: Dual inhibitors of LSD1 and spermine oxidase. MedChemComm 2019, 10(5), 778-790. PMID 31191868

El Bissati, K.; Redel, H.; Ting, L-M; Lykins, J.; McPhillie, M.; Upadhya, R.; Woster, P.M.; Yarlett, N.; Kim, K.; Weiss, L.M.: Novel synthetic polyamines have potent activities in vitro and in vivo by decreasing intracellular spermidine and spermine concentrations. Frontiers Cell. Infect. Microbiol. 2019, 9, online collection, DOI: https://doi.org/10.3389/fcimb.2019.00009, PMID: 3083817.

Holshouser, S.; Dunworth, M.; Murray-Stewart, T.; Peterson, Y.K.; Burger, P.A.; Chen, H.-H.; Casero, Jr., R.A.; Woster, P.M.: Dual inhibitors of LSD1 and spermine oxidase. MedChemComm 2019, epub ahead of print, DOI: https://doi.org/10.1039/C8MD00610E.

Kumarasinghe, I.; Casero, Jr., R.A.; Woster, P.M.: D-Amino acid-substituted cyclic peptides with enhanced activity against lysine-specific demethylase 1. Bioorg. Med. Chem. 2019, submitted.

De Palma RM, Parnham SR, Li Y, Oaks JJ, Peterson YK, Szulc ZM, Roth BM, Xing Y, Ogretmen B.: The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. FASEB J. 2019 Mar 27:fj201802264R. doi: 10.1096/fj.201802264R

Zou Y, Wang X, Sims J, Wang B, Pandey P, Welsh CL, Stone RP, Avery MA, Doerksen RJ, Ferreira D, Anklin C, Valeriote FA, Kelly M, Hamann MT. Computationally Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean.m J Am Chem Soc. 2019 Mar 13;141(10):4338-4344. doi: 10.1021/jacs.8b11403. 

Young, B.F.; Roth, B.M.; Davies, C.: ¹H, ¹³C, and ¹⁵N resonance assignments of N-acetylmuramyl-L-alanine amidase (AmiC) N-terminal domain (NTD) from Neisseria gonorrhoeae. Biomol NMR Assign 2019, 13, 63-66.

Kumarasinghe, I.; Woster, P.M.: Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 with Improved Potency Identified by Alanine Scanning Mutagenesis. Eur. J. Med. Chem. 2018, 148, 210-220. DOI: http://doi.org/10.1016/j.ejmech.2018.01.098; PMID 29459279.

Kirkpatrick, J.E.; Harbin, B.A.; Kirkwood, K.L.; Woster, P.M.: Inhibition of KDM4B Leads to Activated KDM1A, Diminished Bacterial Induced Pro-Inflammatory Cytokine Release and Osteoclastogenesis. Epigenetics 2018, 13(5), 557-572. DOI 10.1080/15592294.2018.1481703; PMID: 29927684

Wang X, Liu J, Pandey P, Fronczek FR, Doerksen RJ, Chen J, Qi X, Zhang P, Ferreira D, Valeriote FA, Sun H, Li S, Hamann MT. Computationally Assisted Assignment of the Kadsuraols, a Class of Chemopreventive Agents for the Control of Liver Cancer. Org Lett. 2018 Sep 21;20(18):5559-5563. doi: 10.1021/acs.orglett.8b02207

Park HB, Tuan NQ, Oh J, Son Y, Hamann MT, Stone R, Kelly M, Oh S, Na M. Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells. Mar Drugs. 2018 Aug 27;16(9). pii: E297. doi: 10.3390/md16090297.

Simithy J, Fuanta NR, Alturki M, Hobrath JV, Wahba AE, Pina I, Rath J, Hamann MT, DeRuiter J, Goodwin DC, Calderón AI. Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids. Biochemistry. 2018 Aug 14;57(32):4923-4933. doi: 10.1021/acs.biochem.8b00231. Epub 2018 Jul 31.

Liu DS, Rong XG, Kang HH, Ma LY, Hamann MT, Liu WZ. Raistrickiones A-E from a Highly Productive Strain ofPenicillium raistrickiiGenerated through Thermo Change. Mar Drugs. 2018 Jun 18;16(6). pii: E213. doi: 10.3390/md16060213.

Chen XY, Zhang T, Wang X, Hamann MT, Kang J, Yu DQ, Chen RY. A Chemical Investigation of the Leaves ofMorus albaL. Molecules. 2018 Apr 26;23(5). pii: E1018. doi: 10.3390/molecules23051018.

Simithy J, Fuanta NR, Hobrath JV, Kochanowska-Karamyan A, Hamann MT, Goodwin DC, Calderón AI.        Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinoneBiochim Biophys Acta Proteins Proteom. 2018 May - Jun;1866(5-6):731-739. doi: 10.1016/j.bbapap.2018.04.007.

Liu J, Pandey P, Wang X, Qi X, Chen J, Sun H, Zhang P, Ding Y, Ferreira D, Doerksen RJ, Hamann MT, Li S.         Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata. J Nat Prod. 2018 Apr 27;81(4):846-857. doi: 10.1021/acs.jnatprod.7b00934.

Wang X, Liu J, Pandey P, Chen J, Fronczek FR, Parnham S, Qi X, Doerksen RJ, Ferreira D, Sun H, Li S, Hamann MT. Assignment of the absolute configuration of hepatoprotective highly oxygenated triterpenoids using X-ray, ECD, NMR J-based configurational analysis and HSQC overlay experiments. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3089-3095. doi: 10.1016/j.bbagen.2017.09.001. Epub 2017 Sep 15.

Ibrahim MA, El-Alfy AT, Ezel K, Radwan MO, Shilabin AG, Kochanowska-Karamyan AJ, Abd-Alla HI, Otsuka M, Hamann MT. Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space. Mar Drugs. 2017 Aug 9;15(8). pii: E248. doi: 10.3390/md15080248.