The MUSC Institutional Biosafety Committee (MUSC IBC) is registered with the National Institutes of Health Office of Biotechnology Activities. Annual reports are submitted and reviewed to determine compliance with Section IV-B-2-a and IV-B-2-b of the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines). These sections describe the administrative, oversight, review, and reporting functions of the MUSC IBC.