Selected Recent Publications

Selected recent publications that utilized the Orbitrap Elite ETD or the *Orbitrap Fusion Lumos Mass Spectrometer:

Label Free Proteomics

*Hurst KE, Lawrence KA, Robino RA, Ball LE, Chung D, Thaxton JE. Remodeling Translation Primes CD8+ T Cell Antitumor Immunity. Cancer Immunol Res. 2020 Feb 19. pii: canimm.0516.2019.

Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM,  Dalton AC, Wang GY, Townsend DM, Tew KD. Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1. Cancer Res. 2019 Aug 15;79(16):4072-4085.

LC-MS/MS Characterization of Peptides Detected by MALDI-Imaging MS

Angel PM, Schwamborn K, Comte-Walters S, Clift CL, Ball LE, Mehta AS, Drake RR. Extracellular Matrix Imaging of Breast Tissue Pathologies by MALDI-Imaging Mass Spectrometry. Proteomics Clin Appl. 2019 Jan;13(1):e1700152.

Angel PM, Comte-Walters S, Ball LE, Talbot K, Mehta A, Brockbank KGM, Drake RR. Mapping Extracellular Matrix Proteins in Formalin-Fixed, Paraffin-Embedded Tissues by MALDI Imaging Mass Spectrometry. J Proteome Res. 2018 Jan 5;17(1):635-646.


Kruyer A, Ball LE, Townsend DM, Kalivas PW, Uys JD. Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking. PLoS One. 2019 Sep 24;14(9):e0223037.

Zhang J, Ye ZW, Chen W, Manevich Y, Mehrotra S, Ball LE, Janssen-Heininger YM, Tew KD, Townsend DM. S-Glutathionylation of estrogen receptor alpha affects dendritic cell function. J Biol Chem. 2018 Mar 23;293(12):4366-4380. PMCID: PMC5868252

SILAC-based Phosphoproteomics

Williams GR, Bethard JR, Berkaw MN, Nagel AK, Luttrell LM, Ball LE. Exploring  G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods. 2016 Jan 1;92:36-50. PMCID: PMC4696908.

SILAC-based Acetylomics

Pehar M, Ball LE, Sharma DR, Harlan BA, Comte-Walters S, Neely BA, Vargas MR.  Changes in Protein Expression and Lysine Acetylation Induced by Decreased Glutathione Levels in Astrocytes. Mol Cell Proteomics. 2016 Feb;15(2):493-505. PMCID: PMC4739669. *Article featured in Special Issue of Mol Cell Proteomics: Neuroproteomics.

Nitration and Glycation

Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball LE, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M. Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75(NTR) and RAGE Signaling in ALS. Antioxid Redox Signal. 2018 Jun 20;28(18):1587-1602. PMCID: PMC5962334.

O-GlcNAc Modification

Nagel AK, Ball LE. O-GlcNAc modification of the runt-related transcription factor 2 (Runx2) links osteogenesis and nutrient metabolism in bone marrow mesenchymal stem cells.  Mol Cell Proteomics. 2014 Dec;13(12):3381-95. PMCID: PMC4256491 *Article featured on journal cover and website.

Nagel AK, Schilling M, Comte-Walters S, Berkaw MN, Ball LE. Identification of O-linked N-acetylglucosamine (O-GlcNAc)-modified osteoblast proteins by electron transfer dissociation tandem mass spectrometry reveals proteins critical for bone formation. Mol Cell Proteomics. 2013 Apr;12(4):945-55. PMCID: PMC3617341.

Isobaric Tagging (TMT or iTRAQ)

Nimitvilai S, Uys JD, Woodward JJ, Randall PK, Ball LE, Williams RW, Jones BC, Lu L, Grant KA, Mulholland PJ. Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques. J Neurosci. 2017; 29;37(13):3646-3660. PMCID: PMC5373140.

Uys JD, McGuier NS, Gass JT, Griffin WC 3rd, Ball LE, Mulholland PJ. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol. 2016 May;21(3):560-74. PMCID: PMC4573771.


Song JH, Padi SK, Luevano LA, Minden MD, DeAngelo DJ, Hardiman G, Ball LE, Warfel NA, Kraft AS. Insulin receptor substrate 1 is a substrate of the Pim protein kinases. Oncotarget. 2016 Apr 12;7(15):20152-65. PMCID: PMC4991444.