Recent DDC Publications

-Newly identified chemicals preserve mitochondrial capacity and decelerate loss of photoreceptor cells in murine retinal degeneration models.

Beeson Craig; Peterson Yuri; Perron Nathan; Bandyopadhyay Mausumi; Nasarre Cecile; Beeson Gyda; Comer Richard; Lindsey Christopher; Schnellmann Rick; Rohrer Baerbel. Journal of Ocular Pharmacology and Therapeutics, 2021

-Novel hydrazide-bearing HDAC inhibitors and their p53 and FLT3-ITD dependency in anti-leukemia activity.

Xiaoyang Li, Yuqi Jiang, Yuri K. Peterson, Elizabeth S. Inks, Richard A. Himes, Dolloff Nathan, Stephanie Halene, Sherine S.L. Chan, C. James Chou.J Med Chem. 2020 Apr 22. doi: 10.1021

-Dual Inhibitors of LSD1 and Spermine Oxidase

Steven Holshouser, Matthew Dunworth, Tracy Murray Stewart, Yuri K. Peterson, Pieter Burger, Joy Kirkpatrick, Huan-Huan Chen, Robert A. Casero, Jr. and Patrick M. Woster.  Med Chem Comm. 2019 Feb 8;10(5):778-790

-PharML.Bind: Pharmacologic Machine Learning for Protein-Ligand Interactions.

Aaron D. Vose, Jacob Balma, Damon Farnsworth, Kaylie Anderson and Yuri K. Peterson.2019, arXiv: 1911.06105 

-Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.

Kumarasinghe IR, Woster PM., Eur J Med Chem. 2018 Mar 25;148:210-220.

-Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis.

Peterson YK, Nasarre P, Bonilla IV, Hilliard E, Samples J, Morinelli TA, Hill EG, Klauber-DeMore N., Angiogenesis. 2017 Nov;20(4):615-628.