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IRB Reliance Requests

Research Integrity

Reliance is the process of using a single IRB for review of multiple sites or investigators at multiple institutions. Reliance and single IRB review is now required by several federal initiatives.

MUSC is willing to review requests for reliance on an external IRB as well as requests for MUSC to act as the IRB of record. Typically, requests for reliance are submitted to our IRB at two time points:

  1. When studies are in their planning stages, e.g. you are preparing a grant submission or have just been awarded grant funds but are not yet ready to submit your protocol for IRB review
  2. When studies are ready to be submitted for IRB review

In both of these scenarios, the first step in the reliance process is to complete a reliance intake form. The MUSC IRB reliance manager will review the information provided in the reliance request and will contact you with the next steps.

Relying or Reviewing?

Which type of study are you trying to submit? Select the link below for additional information and instructions.


For information on fees charged for studies where MUSC relies on an external IRB or when MUSC serves as the IRB of record, please view the IRB submission information.

Still Have Questions?

For more information, please see the single IRB frequently asked questions (FAQs).

Please contact the IRB Reliance Manager for questions about IRB reliance, including:

  • When reliance on external IRBs is allowable
  • How to request reliance on external IRBs
  • Relationships with external IRBs
  • Requesting MUSC IRB approval for non-affiliated investigators
  • NIH single IRB policy

Contact Us

Summer Young, JD, MPH, CIP
IRB Reliance Manager

Related Links

Smart IRB

Click to visit the SPARCRequest website.