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IRB Reliance Requests

Research Integrity

More Information on the NIH Single IRB Policy

Earlier this year, the NIH released a new policy that all sites participating in human subjects research funded by NIH utilize a centralized, single IRB (sIRB). The sIRB will provide IRB review for all participating sites and all sites will be expected to accept the review and approval of the sIRB

What you need to Know about sIRB and the new NIH Policy


Reliance is the process of using a single IRB for review of multiple sites or investigators at multiple institutions. Reliance and single IRB review is now required by several federal initiatives including the National Institutes of Health Single IRB (sIRB) policy, Common Rule revisions, and the 21st Century Cures Act.

You may request the MUSC IRB rely on an external IRB for review and approval of your research, or the MUSC IRB provide approval for non-affiliated investigators or sites.

Quick Guide: Reliance on External IRBs

Quick Guide: MUSC IRB Review for Non-Affiliated Investigators or External Sites

Who Should I Contact About Reliance?

Please contact the IRB Reliance Manager for questions about IRB reliance, including:

  • When reliance on external IRBs is allowable
  • How to request reliance on external IRBs
  • Relationships with external IRBs
  • Requesting MUSC IRB approval for non-affiliated investigators
  • NIH single IRB policy

Contact Us

Reliance Contact Information

Summer Young, JD, MPH, CIP
IRB Reliance Manager