Phenotypic data on Deltagen and Lexicon Genetics KO mice are now available

Phenotypic data on Deltagen and Lexicon Genetics KO mice are now available

The National Institutes of Health (NIH) has contracted with Deltagen Inc. (San Carlos CA) and Lexicon Genetics Incorporated (The Woodlands, TX) to provide NIH and its scientific partners with access to ~251lines of knockout (KO) mice that have been extensively characterized. Notice about the availability of these animals was issued November 15, 2005: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-06-012.html. At that time, the NIH had not yet received the data detailing the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data. These data are now available and can now be found at: www.nih.gov/science/models/mouse/deltagenlexicon/list.html and www.informatics.jax.org/external/ko.

For more information on what knockout mice are, how they are made, what they are used for, and information on how to obtain knockout mice and phenotypic data go to www.nih.gov/science/models/mouse/deltagenlexicon/index.html.

Questions may be directed to Christopher P. Austin, M.D., austinc@mail.nih.gov.

National Institutes of Health (NIH), (http://www.nih.gov/)

Source: Notice Number: NOT-OD-06-020, NIH Guide for Grants and Contracts, Week Ending December 16, 2005, grants.nih.gov/grants/guide/notice-files/NOT-OD-06-020.html