• Additional acceptable fonts are specified. Applicants may now use Arial, Helvetica, Palatino Linotype, or Georgia typeface. The font size must be 11 points or larger. (A Symbol font may be used to insert Greek letters or special characters; the font size requirement still applies.)
• Instructions for the budget fields on the Face Page and the various Budget Form Pages have been revised to provide clearer guidance for applications that include consortium F&A costs.
• A clarification has been made regarding Appendix material. Appendix material can be two-sided as appropriate. While the font requirements imposed in the rest of the application do not apply to the Appendix, all material must be clearly legible.
• Minor formatting revisions have been made to some form pages to improve usability.
• Significant revisions have been made in Part II, Human Subjects Research Supplement, to address NIH implementation of OHRP Guidance on research involving coded private information or biological specimens. Minor revisions and formatting changes have been also been made in the PHS 398, Parts I and III.
• On Form Page 3, Research Grant Table of Contents, the ordering of items in the Human Subjects Research section of the Research Plan has been revised.
• Chapter V of the PHS 398 has been revised to reflect that the modular budget format no longer applies to SBIR/STTR grant applications.

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