Professor, Baxter Laboratory in Genetic Pharmacology, Department of Microbiology and Immunology, Stanford University
Director, Proteomics Center at Stanford University
Dr. Nolan’s laboratory at the Stanford University School of Medicine focuses on the analysis of biological events at the single cell level using novel genetic and FACS-based approaches at the intersection of immunology, autoimmunity, biochemistry, and cancer. The laboratory studies phospho-protein immune cell and cancer signaling, and other metabolic parameters by analysis of biochemical functions at the single cell level in primary cell populations. This includes interrogation of cancer (Cell, 2004) and immune signaling networks in complex cell populations (Science, 2005), and using multiparameter data to stratify signaling maps from patient samples, (Cancer Cell, 2008). Other major interest areas of the laboratory include mapping of signaling networks within complex populations of immune cells, developing systems biology approaches to develop an atlas of immune cell differentiation, the development of mechanism-based diagnostics for use in clinical trial studies. He is the Director of Stanford’s NHLBI Proteomics Center.
Dr. Nolan received his Ph.D. in Genetics at Stanford University under the mentorship of Leonard and Leonore Herzenberg (co-developers of the Fluorescence Activated Cell Sorter) where he worked on the cloning of CD8 and development of the first single cell reporter gene assays. Dr. Nolan did his postdoctoral work in the laboratory of Nobelist David Baltimore at MIT, where he cloned and characterized the p65/RelA subunit of NFκB, a central molecule in inflammation and cancer biology. While working in the Baltimore lab, he co-developed the 293-based retroviral systems that are now a mainstay of retroviral and lentiviral production in research and gene therapy.
Dr. Nolan is a tenured Professor in the Department of Microbiology and Immunology at Stanford University. He has published over 130 articles (biochemistry, gene cloning and characterization, virology immunology, transcriptional biology and signaling). He holds over a dozen patents in the biotechnology arena, and was honored as one of the top 25 inventors at Stanford University. He was the scientific founder, and was Chair of the scientific advisory board of Rigel Pharmaceuticals (a NASDAQ company); was a co-founder of the limited liability company that led to the creation of CellGate, a drug delivery company; and is the scientific Founder and Chairman of the SAB of Nodality, Inc., a venture funded company researching personalized diagnostics based on single cell interrogations of signaling networks in diseased cells.